I'll start by opening hedweb.com and exploring its main pages to identify factual inaccuracies and outdated content.

The main page appears to be frames-based (typical of 1990s sites). Let me explore its structure and key subpages.

The user's own site — this is David Pearce's HedWeb. I'll systematically review the main pages for factual errors and outdated content. Let me fetch the key pages.

The site is large. Let me locate the URLs of the main subpages via search.

Now let me fetch the main content pages to review their factual claims.

The 2026 Abolitionist Project edition is the flagship new page. Let me read it fully, in slices.

Now let me examine the MDMA/Utopian Pharmacology page and the Good Drug Guide, which contain dense pharmacology facts.

The MDMA history section checks out largely, but I spotted a garbled sentence and outdated nav labels. Let me read the rest of the MDMA page.

The MDMA page is clearly a 2002–2014 era document with many stale claims. Now let me check the HI chapters and Utopian Neuroscience for outdated science claims.

Now let me verify two specific claims in the 2026 Abolitionist Project: the "2025 genome-edited animals" milestone and the "several hundred approved gene therapies" figure.

Confirmed: gene therapy approvals are ~68 globally (not "several hundred"), and MDMA therapy was rejected by FDA in 2024. Let me check a few more pages for staleness and nav inconsistencies.

Let me scan the Good Drug Guide 2026 for concrete factual claims to verify.

Let me check a few more legacy pages (Future Opioids, Utopian Surgery, Reproductive Revolution) for stale claims, and verify the zuranolone approval claim.

I now have a solid set of findings. Let me load the rich-ui skill to present the findings list properly.

Let me do a final verification pass on two remaining claims: the 2025 "hedonic set-point animals" milestone and CERC-501's current status.

I have everything I need. Let me grab the citation URIs for the key external facts before compiling the report.

I reviewed the main pages of hedweb.com — the homepage, the HI abstract/intro, the 2026 Abolitionist Project, the Good Drug Guide 2026, Utopian Pharmacology (MDMA), Future Opioids, Wirehead, Utopian Neuroscience, the Reproductive Revolution, and the book/navigation pages. Here's the full fix list:

🔴 Factual inaccuracies

The Abolitionist Project (2026) ( page)

• "Several hundred gene therapies have received regulatory approval worldwide" — inflated roughly five-fold. The ASGCT landscape reports count about 68 approved gene/RNA therapies globally ( ASGCT). Consider "dozens".
• "Psychedelic therapies… have entered mainstream medicine after seventy years of suppression" — doubly inaccurate. The FDA issued a Complete Response Letter rejecting MDMA-assisted therapy for PTSD in August 2024, and psilocybin remains unapproved everywhere ( Lykos PR). And the page itself dates the suppression to the 1970 Controlled Substances Act — that's ~56 years, not seventy; the two statements are internally inconsistent.
• 2025 milestone: "the first genome-edited animals with substantially elevated hedonic set-points… via the mu-opioid and FAAH systems" — I could find no public study supporting this, and "first" is questionable anyway (FAAH-knockout mice date to 2001). It needs a citation or reframing.
• Minor: the milestone table dates the first in-human CRISPR trial to 2017 — the first was in China in late 2016 (2017 was the first US trial). The Cambridge Declaration paraphrase ("including fish and many invertebrates") also over-reaches: the Declaration names mammals, birds and octopuses specifically.

The Good Drug Guide 2026 ( page)

• Zuranolone "approved for major depressive disorder and postpartum depression" — wrong. The FDA approved Zurzuvae for postpartum depression only and issued a Complete Response Letter rejecting the MDD indication ( Sage announcement).
• "Agenapsis and Sage Therapeutics" — "Agenapsis" doesn't exist as a company or pipeline entity; Sage/Biogen's neurosteroid candidates are SAGE-718, SAGE-324, etc. Likely a garbled name.

Future Opioids ( page)

• "CERC-501… is currently (late 2016) undergoing trials as an antidepressant" — now doubly out of date: J&J discontinued the aticaprant (CERC-501) Phase 3 depression programme in March 2025 for insufficient efficacy ( MPR,  J&J statement). This also weakens AP-2026's optimism about kappa antagonists "showing promise" in preliminary human trials — worth acknowledging.

🟡 Stale content (updates needed)

The MDMA/Utopian Pharmacology page ( page) is the biggest candidate for refresh — its clinical/legal framing froze around 2014:

• "MAPS has been seeking… FDA approval for controlled trials" — Phase 2 and 3 trials (MAPP1/MAPP2) have since been completed, and the application was rejected by the FDA in 2024 ( Lykos PR); Australia has allowed authorised MDMA prescribing since July 2023.
• "MDMA's stunning short-term results make double-blind, placebo-controlled trials effectively impossible" — contradicted by the blinded Phase 2/3 RCTs that have now been run.
• Early-2000s market data: "perhaps 10–15% of tablets contain MDMA as the sole active ingredient" (current EU monitoring finds high-purity MDMA in most tablets), pill prices of $7–25, "as of 2014", and "Russian-Israeli syndicates… are now increasingly active".
• Textual fixes: the garbled sentence "MDA was first synthesized by Carl Mannich and Willy Jacobsohn synthesized MDA in 1912", and the typo "Harpers Bazaar" (Harper's Bazaar).

🟠 Site consistency

• Old navigation labels on at least three pages (HI: Philosophical Foundations, Good Drug Guide placeholder, Future Opioids) still say "Social Media (2024)" / "Quora Answers (2015-24)" while the rest of the site says (2026) / (2015-26).
• Unresolved "(202?)" placeholder dates on three book pages.
• Two near-duplicate HI abstracts (hedab.htm / hedabuti.html) diverge in wording; the current phrase "ambitious, implausible, but technically feasible" contradicts the homepage's "hugely ambitious but technically feasible" and looks like a leftover.
• The 2007 Abolitionist Project has no banner pointing readers to the 2026 edition.

✅ Checked out fine

The MDMA history section (Merck 1912 patent, Shulgin 1965/1976, PiHKAL 1991, MDA 1912, Texas/Boston groups), Jo Cameron's FAAH-OUT profile, CRISPR-Cas9 (2012), esketamine approval (2019), Oregon/Colorado psilocybin, fluoxetine (1987), the Cipriani 2018 meta-analysis, brexanolone (2019), rapastinel's failed Phase 3, the Dalai Lama quote (SfN, Nov 2005), and the UK Misuse of Drugs/Criminal Justice Act history all verified correct.

Want me to draft the corrected wording for any of these pages, or dig deeper into a section I only skimmed (e.g., the Quora answers archive or the HI chapters)?